Priti Patel has demanded an explanation from Twitter and Instagram over the length of time it took to remove "abhorrent" posts made by Wiley.
Police are currently investigating a series of antisemitic comments posted on the Grime artist's social media accounts.
The Home Secretary tweeted on Sunday: "The antisemitic posts from Wiley are abhorrent.
"They should not have been able to remain on Twitter and Instagram for so long and I have asked them for a full explanation.
"Social media companies must act much faster to remove such appalling hatred from their platforms."
The antisemitic posts from Wiley are abhorrent.
They should not have been able to remain on Twitter and Instagram for so long and I have asked them for a full explanation.
Social media companies must act much faster to remove such appalling hatred from their platforms.
— Priti Patel (@pritipatel) July 26, 2020
Twitter was accused of "ignoring antisemitism" as Wiley's tweets were still visible 12 hours after they were first posted.
A number of tweets have since been removed and the 41-year-old has been issued a seven-day ban by the site.
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Twitter previously said Wiley's account had been temporarily locked "for violating our hateful conduct policy", while Facebook said there was "no place for hate speech on Instagram".
The Metropolitan Police said on Saturday: "The Met takes all reports of antisemitism extremely seriously. The relevant material is being assessed."
Meanwhile, Wiley's management company, A-List Management, "cut all ties" with the star.
The artist's now former manager, John Woolf, who is Jewish, wrote on Twitter: "Following Wiley's antisemitic tweets today we at @A_ListMGMT have cut all ties with him. There is no place in society for antisemitism."
He had earlier said he did not support or condone what Wiley posted but that he would speak to him privately and "help educate him".
However, in a video on Instagram, Wiley appeared to say it was him who had cut ties with his management.
Other MPs criticised Twitter for allowing the tweets to remain visible.
Labour MP Jess Phillips said on Saturday: "Just seen all the Wiley stuff. Why on earth have @TwiRead More – Source